Journal of Research Administration

Abstract

The clear cell variant of Oral Squamous Cell Carcinoma (OSCC) is a rare histological subtype, in the oral cavity. This case involves a 40-year-old male patient who presented with a growth on the right lateral border of the tongue. Histopathological analysis showed proliferating surface epithelium over a cellular stroma. The epithelium exhibited dysplastic features and clear cells extended deep into the muscular layer, suggesting well-differentiated oral squamous cell carcinoma. Periodic Acid-Schiff (PAS) staining showed negative in clear cells. Immunohistochemistry for cytokeratin (AE1/AE3) was positive in both clear and other epithelial cells, while Vimentin showed a strong positive reaction only in the tumour stroma. Based on these special stains and IHC markers, the diagnosis of clear cell variant of OSCC was confirmed. This rare variant is known to be aggressive and presents diagnostic challenges, underscoring the need for more cases to be reported to better understand its biological behaviour and prognosis.